The Shumway Lectures: George Fein
Thursday April 26, 2012
Location: Mathematical Sciences Building 1147 (Colloquium Room), UC Davis
Lecture Time: 4:10 pm
Please join us for cake and coffee at 3:30pm, prior to the Lecture.
Following the Lecture, a catered Reception will be held in the lobby of the Math Sciences Building
Speaker: Dr. George Fein, President, Neurobehavioral Research Inc.
Title: The 'Noise' in ERP Studies of Alcoholics Contains a Signal of Potential Crucial Importance
Abstract: Event-Related Potentials (ERPs) consist of average stimulus-phase-locked (evoked) brain activity. Over the past 30 years, the ERP to targets in visual target detection tasks has consistently been shown to be reduced in alcoholics and in individuals at high genetic risk for developing alcoholism. This finding has formed an important basis for research on the genetics of alcoholism (it is a central variable in research conducted by the Consortium On the Genetics of Alcoholism (COGA). The is true whether this evoked brain response is examined in the time or frequency domain. Recently, we have shown that there is important alcohol-related information in the non-stimulus-phase-locked (induced) activity in the theta frequency range. We will present data from four samples suggesting that increased (in comparison to the decreased evoked activity) induced theta may likely be a biomarker for the morbid effects of alcohol abuse on brain function.
Dr. George Fein is President and Senior Scientist, Neurobehavioral Research, Inc. (NRI) which he formed in 1999 after 24 years at UCSF where he held academic titles as Professor of Medical Psychology and Professor of Radiology and taught advanced courses in Biostatistics. He has over 150 publications related to the clinical and cognitive neuroscience of addiction and the development of technology such as fMRI and EEG to support such research. NRI has offices in Maui and a large laboratory and office in Honolulu with extensive support funding from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) of the NIH.