Math-Stat Colloquium: Amit Singer (Princeton U)


Department of Statistics
Department of Mathematics
University of California, Davis

Tuesday, May 21st, 4:10pm in MSB 1147 (Colloquium Room)
Refreshments at 3:30pm in Colloquium Room prior to the talk

Speaker: Amit Singer
(Math & PACM, Princeton University)

Title: Three-dimensional structure determination of molecules without crystallization

Abstract: Cryo-electron microscopy (EM) is used to acquire noisy 2D projection images of thousands of individual, identical frozen-hydrated macromolecules at random unknown orientations and positions. The goal is to reconstruct the 3D structure of the macromolecule with sufficiently high resolution. We will discuss algorithms for solving the cryo-EM problem and their relation to other branches of mathematics such as tomography, random matrix theory, representation theory, spectral geometry, convex optimization and semidefinite programming.