STA 290 Seminar: Patrice Koehl (UC Davis)

Statistics Seminar: STA 290

Thursday, November 3rd, 2011 at 4.10pm, MSB 1147 (Colloquium Room)

Speaker: Patrice Koehl (Dept Computer Science/Genome Center, UC Davis)

Title: Protein structure and sequence spaces: how big are they?

Abstract: Gene family and protein structure family sizes are known to vary widely, from orphans to considerably populated sets of far-diverged homologs. The underlying causes behind these observed irregularities in sequence space remain unclear. In this seminar, I will show that geometry and thermodynamics are key elements for measuring the ability of a protein to accept mutations without losing its structure.